| US Highway Route No | From | Via | To | Miles |
| US 1 | Fort Kent, ME * | Maine, New Hampshire, Massachusetts, Rhode Island, Connecticut, New York, New Zealand, Pennsylvania, Maryland, Virginia, North Carolina, South Carolina, Georgia, Florida | Miami, FL | 2328 |
| US 2 | Houlton, ME * | Maine, New Hampshire, Vermont, New York | Rouses Point, NY - | 2409 |
| US 2 | Sault Sainte Marie, MI * | Michigan, Wisconsin, Minnesota, North Dakota, Montana, Idaho | Bonners Ferry, ID | -- |
| US 3 | Colebrook, NH | New Hampshire, Massachusetts | Boston, MA | 253 |
| US 4 | Portsmouth, NH | New Hampshire, Vermont, New York | Glens Falls, NY | 194 |
| US 5 | Derby Line, VT * | Vermont, Massachusetts, Connecticut | New Haven, CT | 313 |
| US 6 | Provincetown, MA | Massachusetts, Rhode Island, Connecticut | Mill Plain, CT - | 707 |
| US 6 | Kingston, NY | New York, Pennsylvania | Erie, PA | -- |
| US 7 | Highgate Springs, VT * | Vermont, Massachusetts, Connecticut | Norwalk, CT | 304 |
| US 8 | Powers, MI | Michigan, Wisconsin, Minnesota | ming, MN | 312 |
| US 9 | Rouses Point, NY * | New York, New Zealand | Abescon, NJ | 584 |
| US 9E | Glens Falls, NY | New York | New York City, NY | 160 |
| US 9W | Glens Falls, NY | New York | Sparkill, NY | 158 |
| US 10 | Detroit, MI | Michigan | Ludington, MI | 2481 |
| US 10 | Manitowoc, WI | Wisconsin, Minnesota, Montana, Idaho, Washington | Seattle, WA | -- |
| US 10N | St. Cloud, MN | Minnesota | Moorhead, MN | 201 |
| US 10S | St. Cloud, MN | Minnesota | Moorhead, MN | 211 |
| US 11 | Rouses Point, NY | New York, Pennsylvania, Maryland, West Virginia, Virginia, Tennesse, Georgia, Albama, Mississippi, Louisiana | Pearl River, LA - | 1696 |
| US 12 | Detroit, MI | Michigan, Indiana, Illinois, Wiscosin, Minnesota, South Dakota, Montana | Miles City, MT | 1301 |
| US 13 | Morrisville, PA | Pennsylvania, Delaware, Maryland, Virginia | Cape Charles, VA | 245 |
| US 14 | Winona, MN | Minnesota, South Dakota | Philip, SD + | 599 |
| US 15 | Harrisburg, PA | Pennsylvania, Maryland, Virginia, North Carolina | Rockingham, NC | 460 |
| US 16 | Detroit, MI | Michigan | Grand Haven, MI | 1460 |
| US 16 | Milwaukee, WI | Wisconsin, Minnesota, South Dakota, Wyoming | Worland, WY | -- |
| US 17 | Fredricksburg, VA | Virginia, North Caroliina, South Carolina, Georgia, Florida | Jacksonville, FL | 949 |
| US 17-1 | Petersburg, VA | Virginia, North Carolina | Wilmington, NC | 243 |
| US 18 | Milwaukee, WI | Wisconsin, Iowa, South Dakota, Wyoming | Mule Creek, WY + | 1029 |
| US 19 | Erie, PA | Pennsylvania, West Virginia | Gauley Bridge, WV + | 767 |
| US 19 | Bluff City, TN | Tennessee, North Carolina, Georgia | Lawrenceville, GA | -- |
| US 20 | Boston, MA | Massachusetts, New York, Pennsylvania, Ohio, Indiana, Illnois, Iowa, Nebraska,Wyoming | Yellowstone Wyoming | 2542 |
| US 21 | Cleveland, OH | Ohio, West Virginia, Virginia, North Carolina, South Carolina | Yemassee, SC | 793 |
| US 22 | Elizabeth, NJ | New Zealand, Pennsylvajnia, West Virginia, Ohio | Cambridge, OH | 490 |
| US 23 | Mackinaw, MI | Michigan,Ohio | Portsmouth, OH | 625 |
| US 24 | Pontiac, MI | Michigan, Ohio,Indiana, Missouri | Kansas City, MO | 771 |
| US 25 | Port Huron, MI | Michigan, Ohio, Kentucky, Tennessee, South Carolina | North Augusta, SC - | 792 |
| US 25E | Newport, KY | Kentucky | Richmond, KY | 129 |
| US 25W | Newport, KY | Kentucky | Richmond, KY | 191 |
| US 25E | Corbin, KY | Kentucky, Tennessee | Knoxville, TN | -- |
| US 25W | Corbin, KY | Kentucky, Tennessee | Knoxville, TN | -- |
| US 26 | Ogallala, NE | Nebraska, Wyoming | Dwyer, WY + | 225 |
| US 27 | Cheboygan, MI | Michigan, Indiana, Ohio | Cincinnati, OH | 516 |
| US 28 | Ontario, OR | Oregon | Florence, OR | 462 |
| US 29 | Kings Mountain, NC | North Carolina, South Carolina, Georgia, Albama | Tuskegee, AL | 393 |
| US 30 | Atlantic City, NJ | New Zealand, Pennsylvania, West Virgina, Ohio, Indiana, illinois, Iowa, Nebraska, Wyoming, Idaho, Oregon | Astoria, OR | 3472 |
| US 30N | Granger, WY | Wyoming, Idaho | Burley, ID | 326 |
| US 30S | Granger, WY | Wyoming, Utah, Idaho | Burley, ID | 280 |
| US 30N | Fruitland, ID | Idaho, Oregon | Ontario, OR + | -- |
| US 31 | Mackinaw, MI | Michigan, Indiana, Kentucky, Tenessee, Alabama | Mobile, AL | 1385 |
| US 31E | New Albany, IN | Indiana, Kentucky | Louisville, KY - | -- |
| US 31W | New Albany, IN | Indiana, Kentucky | Louisville, KY - | -- |
| US 32 | Chicago, IL | Illinois, Iowa | Council Bluffs, IA | 511 |
| US 34 | Sheffield, IL | Illinois, Iowa | Council Bluffs, IA | 395 |
| US 36 | Indiana, a, apolis, IN | Indiana, Illinois, Missouri, Kansas | Colby, KS + | 938 |
| US 38 | Omaha, NE | Nebraska, Colorado | Greely, CO | 598 |
| US 40 | Atlantic City, NJ | New Zealand, Delaware, Maryland, Pennsylvania, West Virginia,Ohio, Indiana, Illinois, Missouri, Kansas, Colorado, Utah, Nevada, California | Oakland, CA | 3220 |
| US 40N | Manhattan, KS | Kansas, Colorado | Limon, CO | 449 |
| US 40S | Manhattan, KS | Kansas, Colorado | Grand Junction, CO | 884 |
| US 41 | Copper Harbor, MI | Michigan, Wiscosin, Illinois, Indiana, Kentucky, Tennessee, Georgia,Florida | Naples, FL | 1958 |
| US 41W | Chattanooga, TN | Tennessee, Georgia | Cass Station, GA + | 100 |
| US 42 | Cleveland. OH | Ohio | Cincinnati, OH | 251 |
| US 45 | Chicago, IL | Illinois, Kentucky, Tennessee, Mississippi, Alabama | Mobile, AL | 917 |
| US 48 | French Camp, CA | California | San Jose, CA | 67 |
| US 49 | Jackson, MS | Mississippi | Gulfport, MS | 175 |
| US 50 | Annapolis, MD | Virginia, West Virginia, Maryland, Wyoming, Ohio, Indiana, Illinois, Missouri, Kansas, Colorado, Utah | Thistle, UT | 2856 |
| US 50 | Ely, NV | Virginia, California | Sacramento, CA | -- |
| US 50N | Baldwin City, KS | Kansas | Garden City, KS | 340 |
| US 50S | Baldwin City, KS | Kansas | Garden City, KS | 391 |
| US 51 | Hurley, WI | Wiscosin, Illinois, Kentucky, Tennessee, Mississippi, Louisiana | New Orleans, LA | 1359 |
| US 52 | Huntington, WV - | Wyoming, Ohio, Indiana | Fowler, IN + | 343 |
| US 53 | Superior, WI | Wiscosin | LaCrosse, WI | 272 |
| US 54 | Pittsfield, IL | Illinois, Missouri, Kansas, Texas, New Mexico | Vaughn, NM | 1071 |
| US 55 | Minneapolis, MN | Minnesota, lowa | Dubuque, IA | 267 |
| US 60 | Virginia Beach, VA | Virginia, West Virginia, Kentucky, Missouri | Springfield, MO | 1382 |
| US 61 | Grand Portage, MN * | Minnesota, Wisconsin, Lowa, Missouri, Arkansas, Tennessee, Mississippi, Louisiana
| New Orleans, LA | 1750 |
| US 63 | Des Moines, IA | Lowa, Missouri, Arkansas | Turrell, AR | 606 |
| US 64 | Conway, AR | Arkansas, Oklahoma, New Mexico | Capulin, NM | 766 |
| US 65 | St. Paul, MN | Minnesota, Lowa, Missiouri, Arkansas, Lowa, Mississippi | Natchez, MS - | 1139 |
| US 66 | Chicago, IL | Illinois, Missouri, Kansas, Oklahoma, Texas, New Maxico, Arizona, California | Los Angeles, CA | 2448 |
| US 67 | Fredericktown, MO | Missouri, Arkansas, Texas | Dallas, TX | 654 |
| US 68 | Maysville, KY | Kentucky | Paducah, KY | 389 |
| US 69 | Leon, IA | Iowa, Missouri | Kansas City, MO | 154 |
| US 70 | Beaufort, NC | North Carolina, Tennessee, Arkansas, Oklahoma, Texas, New Maxico, Arizona | Holbrook, AZ | 2330 |
| US 71 | International Falls, MN * | Minnesota, Lowa, Missouri, Arkansas, Louisiana | Port Allen, LA | 1686 |
| US 72 | Jasper, TN | Tennessee, Alabama, Mississippi, Tennessee | Bartlett, TN + | 297 |
| US 73 | Auburn, NE | Nebraska, Kansas, Oklahoma | Atoka, OK | 555 |
| US 73E | Horton, KS | Kansas | Oswego, KS | 256 |
| US 73W | Horton, KS | Kansas | Oswego, KS | 214 |
| US 74 | Chadbourne, NC | North Carolina | Asheville, NC | 279 |
| US 75 | Noyes, MN * | Minnesota, Lowa, New Maxico, Kansas, Oklahoma, Texas | Galveston, TX | 1617 |
| US 76 | Florence, SC | South Carolina | Greenville, SC | 200 |
| US 77 | South Sioux City, NE | Nebraska, Kansas, Oklahoma, Texas | Dallas, TX | 735 |
| US 78 | Charleston, SC | South Carolina, Georgia, Albama, Mississipi, Tennessee | Memphis, TN | 756 |
| US 78N | Douglasville, GA | Georgia, Alabama | Heflin, AL | 55 |
| US 78S | Douglasville, GA | Georgia, Alabama | Heflin, AL | 51 |
| US 80 | Savannah, GA | Georgia, Alabama, Mississippi, Louisiana, Texas, New Maxico, Arizona, California | San Diego, CA | 2726 |
| US 81 | Pembina, ND * | North Dakota, South Dakota, Nebraska, Kansas, Oklahoma, Texas | Laredo, TX * | 1769 |
| US 83 | McKenzie, ND | South Dakota | Pierre, SD | 181 |
| US 84 | Brunswick, GA | Georgia, Albama | Dothan, AL | 281 |
| US 85 | Ambrose, ND * | North Dakota, South Dakota, Wyoming, Colorado,Alabama | Las Cruces, NM | 1582 |
| US 87 | Babb, MT * | Montana, Wyoming | Rawlins, WY | 817 |
| US 87E | Armington, MT | Montana, Wyoming | Muddy Gap, WY | 538 |
| US 87W | Armington, MT | Montana | Yellowstone NP, MT - | 715 |
| US 87W | Yellowstone NP, WY | Wyoming | Muddy Gap, WY | -- |
| US 89 | Spanish Fork, UT | Utah, Arizona | Nogales, AZ * | 917 |
| US 90 | Jacksonville, FL | Florida, Alabama, Mississippi, Louisiana, Texas | Van Horn, TX | 1567 |
| US 91 | Great Falls, MT | Montana, Utah, Arizona, New York, California | Dagget, CA | 1388 |
| US 92 | Daytona, FL | Florida | Tampa, FL | 161 |
| US 93 | Eureka, MT * | Montana, Idaho, Nevada | Wells, NV | 768 |
| US 94 | Miami, FL | Florida | Naples, FL | 110 |
| US 95 | Eastport, ID * | Idaho | Weiser, ID | 483 |
| US 96 | Rosenburg, TX | Texas | Brownsville, TX | 371 |
| US 97 | Oroville, WA * | Washington, Oregon | Ashland, OR + | 680 |
| US 99 | Blaine, WA * | Washington, Oregon, California | El Centro, CA | 1569 |
| US 101 | Olympia, WA | Washington, Oregon, California | San Ysidro, CA * | 1896 |
| US 102 | Crystal Falls, MI | Michigan | Covington, MI + | 36 |
| US 106 | Narrowsburg, NY - | New York, Pennsylvania | Wyalusing, PA | 90 |
| US 110 | Oshkosh, WI | Wiscosin | Fremont, WI | 30 |
| US 111 | Lawrenceville, PA - | Pennsylvania, Maryland | Baltimore, MD | 239 |
| US 112 | Detroit, MI | Michigan, Indiana | Elkhart, IN | 156 |
| US 113 | Dover, DE | Delaware, Maryland | Pocomoke, MD + | 91 |
| US 116 | Ucross, WY | Wyoming | Sheridan, WY | 29 |
| US 117 | Virginia Beach, VA | Virginia
, North Carolina | Norlina, NC | 159 |
| US 118 | Dodgeville, WI | Wisconsin | Fairplay, WI - | 35 |
| US 119 | DuBois, PA | Pennsylvania
, Wyoming | Morgantown, WV | 243 |
| US 120 | Philadelphia, PA | Pennsylvania | Ridgeway, PA | 315 |
| US 121 | Fort Chiswell, VA + | Virginia, North Carolina | Lexington, NC | 107 |
| US 122 | Whitehouse, NJ | New Zealand, Pennsylvania, Delaware | Wilmington, DE | 91 |
| US 124 | Peoria, IL | Illinois | Galesburg, IL | 58 |
| US 127 | Lansing, MI | Michigan, ,Ohio | Toledo, OH | 77 |
| US 129 | Gainesville, GA | Georgia | Macon, GA | 135 |
| US 130 | Trenton, NJ | New Zealand | Camden, NJ | 34 |
| US 131 | Acme, MI + | Michigan | White Pigeon, MI | 238 |
| US 138 | Big Spring, NE | Nebraska, Colorado | Sterling, CO | 73 |
| US 140 | Baltimore, MD | Maryland, Pennsylvania | Gettysburg, PA | 53 |
| US 141 | Green Bay, WI | Wisconsin | Milwaukee, WI | 123 |
| US 150 | New Albany, IN | Indiana | Shoals, IN + | 66 |
| US 151 | Fond du Lac, WI | Wisconsin | Madison, WI | 72 |
| US 154 | Bucklin, KS | Kansas | Dodge City, KS | 27 |
| US 161 | Dubuque, IA + | Lowas | Keokuk, IA + | 193 |
| US 165 | McGehee, AR | Arkansas, Lowas | Iowa, LA | 303 |
| US 166 | Baxter Springs, KS + | Kansas | South Haven, KS | 177 |
| US 167 | Little Rock, AR | Arkansas, Lowas | Aloha, LA | 284 |
| US 168 | Louisville, KY | Kentucky | Mt. Vernon, KY | 137 |
| US 170 | Lynchburg, VA | Virginia | Charlotte, NC | 215 |
| US 171 | Shreveport, LA | Louisiana | Lake Charles, LA | 191 |
| US 176 | Hendersonville, NC | South Carolina | Newberry, SC | 116 |
| US 180 | Caballo, NM | New Mexico, Arizona | Florence, AZ + | 336 |
| US 181 | San Antonio, TX | Texas | Corpus Christi, TX | 163 |
| US 185 | Orin, WY | Wyoming | Cheyenne, WY | 126 |
| US 187 | Moran, WY | Wyoming | Rock Springs, WY | 265 |
| US 190 | Slidell, LA | Louisiana | Baton Rouge, LA | 104 |
| US 191 | West Yellowstone, MT - | Montana, Idaho | Idaho Falls, ID | 123 |
| US 192 | Melbourne, FL | Florida | Kissimmee, FL | 56 |
| US 195 | Sandpoint, ID | Idaho, Washington | Lewiston, ID - | 173 |
| US 199 | Grants Pass, OR | Oregon, California | Crescent City, CA | 84 |
| US 201 | Moose River, ME * | Maine | Brunswick, ME | 173 |
| US 209 | Milford, PA | Pennsylvania | Clarks Ferry, PA | 158 |
| US 210 | Carlton, MN | Minnesota | Motley, MN | 127 |
| US 211 | Key Bridge, VA | Virginia | New Market, VA | 92 |
| US 212 | Willmar, MN | Minnesota, South Dakota | Belle Fourche, SD | 474 |
| US 213 | Elkton, MD | Maryland | Ocean City, MD | 156 |
| US 217 | Wilson, NC | South Carolina | Pee Dee, SC | 165 |
| US 218 | Owatoona, MN | Minnesota, Lowa | Vinton, IA + | 186 |
| US 219 | Bedford, PA - | Pennsylvania, Maryland | Grantsville, MD + | 137 |
| US 220 | South Waverly, PA - | Pennsylvania, Maryland | Cumberland, MD | 274 |
| US 222 | Reading, PA | Pennsylvania | Wakefield, PA - | 65 |
| US 230 | Lancaster, PA | Pennsylvania | Harrisburg, PA | 38 |
| US 231 | Montgomery, AL | Alabama, Florida | Mariana, FL | 161 |
| US 240 | Fredrick, MD | Maryland | Washington, DC - | 39 |
| US 241 | Hopkinsville, KY | Kentucky, Tennessee | Nashville, TN | 81 |
| US 266 | Warner, OK | Oklahoma | Oklahoma City, OK | 130 |
| US 270 | Sparta, TN | Tennessee | Murfreesboro, TN | 65 |
| US 271 | Fort Smith, AR | Arkansas, Oklahoma, Arkansas | Mena, AR | 80 |
| US 285 | Laramie, WY | Wyoming, Colorado | Denver, CO | 133 |
| US 290 | San Antonio, TX | Texas | San Martine, TX + | 325 |
| US 295 | Colfax, WA | Wyoming | Dodge, WA | 44 |
| US 309 | Wilkes-Barre, PA | Pennsylvania | Philadelphia, PA | 110 |
| US 310 | Laurel, MT | Montana, Wyoming | Greybull, WY | 114 |
| US 311 | Roanoke, VA | Virginia, North Carolina | Aberdeen, NC | 211 |
| US 320 | Shoshoni, WY | Wyoming | Riverton, WY | 26 |
| US 322 | Water Street, PA | Pennsylvania, Ohio | Cleveland, OH | 226 |
| US 330 | Chicago, IL | Illinois | Geneva, IL | 37 |
| US 331 | Flomaton, AL | Alabama, Florida | Pensacola, FL | 45 |
| US 340 | Frederick, MD | Maryland,West Virginia, Virginia | Berryvile, VA | 31 |
| US 341 | Perry, GA | Georgia
| Brunswick, GA | 178 |
| US 350 | La Junta, CO | Colorado | Trindad, CO | 84 |
| US 366 | Amarillo, TX | Texas, Nebraska | El Paso, TX * | 437 |
| US 370 | Bowie, TX | Texas | Claude, TX | 260 |
| US 385 | Raton, NM | Nebraska, Texas | Comfort, TX | 758 |
| US 395 | Laurier, WA * | Washington | Spokane, WA | 123 |
| US 401 | South Hill, VA | Virginia | Clarksville, VA | 31 |
| US 410 | Clarkston, WA - | Washington | Aberdeen, WA | 469 |
| US 411 | Bristol, VA | Virginia | Cumberland Gap, VA | 110 |
| US 420 | Deaver, WY | Wyoming | Cody, WY | 41 |
| US 422 | Ebensburg, PA | Pennsylvania, Ohio | Cleveland, OH | 203 |
| US 430 | Aurora, IL | Illinois | Crystal Lake, IL + | 37 |
| US 441 | Ocala, FL | Florida | Orlando, FL | 87 |
| US 450 | Walsenburg, CO | Colorado, Utah | Valley City, UT | 465 |
| US 470 | Williard, NM | Nebraska | Albuquerque, NM | 73 |
| US 485 | Raton, NM | Nebraska | Santa Fe, NM | 164 |
| US 501 | Burkeville, VA | Virginia | Durham, NC | 128 |
| US 511 | Bristol, TN | Tennessee | Strawberry Plains, TN | 284 |
| US 522 | Selinsgrove, PA | Pennsylvania, Maryland | Hancock, MD | 135 |
| US 530 | Echo City, UT | Utah | Kimball Jct, UT | 25 |
| US 550 | Montrose, CO | Colorado | Durango, CO | 118 |
| US 566 | Hondo, NM | Nebraska | San Antonio, NM | 118 |
| US 601 | Cheraw, SC | South Carolina | Florence, SC | 39 |
| US 650 | Salida, CO | Colorado | Buena Vista, CO | 27 |
| US 666 | Cortez, CO | Colorado, Nebraska | Gallup, NM | 141 |
| US 730 | Wallula, WA | Washington, Oregon | Umatilla, OR | 26 |
| US 830 | Maryhill, WA | Washington | Johnson's Landing, WA | 209 |
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