| City Name | County Name | Population (2010) |
|---|
| Philadelphia | Philadelphia | 1,526,006 |
| Pittsburgh | Allegheny | 305,704 |
| Allentown | Lehigh | 118,032 |
| Erie | Erie | 101,786 |
| Reading | Berks | 88,082 |
| Scranton | Lackawanna | 76,089 |
| Bethlehem | Lehigh and Northampton | 74,982 |
| Lancaster | Lancaster | 59,322 |
| Harrisburg | Dauphin | 49,528 |
| Altoona | Blair | 46,320 |
| York | York | 43,718 |
| Wilkes-Barre | Luzerne | 41,498 |
| Chester | Delaware | 33,972 |
| Williamsport | Lycoming | 29,381 |
| Easton | Northampton | 26,800 |
| Lebanon | Lebanon | 25,477 |
| Hazleton | Luzerne | 25,340 |
| New Castle | Lawrence | 23,273 |
| Johnstown | Cambria | 20,978 |
| McKeesport | Allegheny | 19,731 |
| Hermitage | Mercer | 16,220 |
| Greensburg | Westmoreland | 14,892 |
| Pottsville | Schuylkill | 14,324 |
| Sharon | Mercer | 14,038 |
| Butler | Butler | 13,757 |
| Washington | Washington | 13,663 |
| Meadville | Crawford | 13,388 |
| New Kensington | Westmoreland | 13,116 |
|
| City Name | County Name | Population (2010) |
|---|
| Coatesville | Chester | 13,100 |
| Lower Burrell | Westmoreland | 11,761 |
| Oil City | Venango | 10,557 |
| Nanticoke | Luzerne | 10,465 |
| Uniontown | Fayette | 10,372 |
| Sunbury | Northumberland | 9,905 |
| Lock Haven | Clinton | 9,772 |
| Warren | Warren | 9,710 |
| Jeannette | Westmoreland | 9,654 |
| Aliquippa | Beaver | 9,438 |
| Beaver Falls | Beaver | 8,987 |
| Latrobe | Westmoreland | 8,944 |
| Carbondale | Lackawanna | 8,891 |
| Bradford | McKean | 8,770 |
| DuBois | Clearfield | 7,794 |
| Pittston | Luzerne | 7,739 |
| Monessen | Westmoreland | 7,720 |
| Connellsville | Fayette | 7,637 |
| Shamokin | Northumberland | 7,374 |
| Clairton | Allegheny | 6,796 |
| Corry | Erie | 6,605 |
| Franklin | Venango | 6,545 |
| Titusville | Crawford | 5,602 |
| Duquesne | Allegheny | 5,565 |
| Arnold | Westmoreland | 5,157 |
| Farrell | Mercer | 5,111 |
| Monongahela | Washington | 4,300 |
| Parker | Armstrong | 840 |
| St. Marys | Elk | 13,070 |
|
