| Time Period |
Reason for Vacancy |
| 1812-1813 |
George Clinton died in office |
| 1814-1817 |
Elbridge Gerry died in office |
| 1832-1833 |
John C. Calhoun resigned from office |
| 1841-1845 |
John Tyler became President upon the death of William Henry Harrison |
| 1850-1853 |
Millard Fillmore became President upon the death of Zachary Taylor |
| 1853-1857 |
William King died in office |
| 1865-1869 |
Andrew Johnson became President upon the death of Abraham Lincoln |
| 1875-1877 |
Henry Wilson died in office |
| 1881-1885 |
Chester Arthur became President upon the death of James Garfield |
| 1885-1889 |
Thomas Hendricks died in office |
| 1899-1901 |
Garret Hobart died in office |
| 1901-1905 |
Theodore Roosevelt became President upon the death of William McKinley |
| 1912-1913 |
James S. Sherman died in office |
| 1923-1925 |
Calvin Coolidge became President upon the death of Warren G. Harding |
| 1945-1949 |
Harry Truman became President upon the death of Franklin D. Roosevelt |
| 1963-1965 |
Lyndon Johnson became President upon the death of John F. Kennedy |
| 1973 |
Spiro Agnew resigned from office |
| 1974 |
Gerald Ford became President upon the resignation of Richard Nixon |
